Verfügbarkeit: Molecular mechanisms of spondyloarthropathies

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Titel:	Molecular mechanisms of spondyloarthropathies
Von:	ed. by Carlos López-Larrea ... [Participants: Allen P. Amandarajah ...]
Person:	López-Larrea, Carlos Anandarajah, Allen P. 1953- Sonstige
Weitere beteiligte Personen:	López-Larrea, Carlos 1953- (HerausgeberIn)
Format:	Buch
Sprache:	Englisch
Veröffentlicht:	New York, NY Springer Science + Business Media LLC [u.a.] 2009
Schriftenreihe:	Advances in experimental medicine and biology 649
Notation:	YK 3017
Schlagwörter:	Spondylarthropathies > genetics Spondyloarthropathies > Molecular aspects Spondylarthrose Wirbelsäulenkrankheit
Medienzugang:	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017740264&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
Umfang:	XXV, 314 S. Ill., graph. Darst., Kt. 235 mm x 155 mm
ISBN:	9781441902979

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245	1	0	\|a Molecular mechanisms of spondyloarthropathies \|c ed. by Carlos López-Larrea ... [Participants: Allen P. Amandarajah ...]
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Datensatz im Suchindex

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adam_text	CONTENTS 1. CLINICAL ASSESSMENT IN THE SPONDYLOARTHROPATHIES ..... 1 Ruth Wittoek and Herman Mielants Abstract .................................................................................................................................1 Introduction ..........................................................................................................................1 Ankylosing Spondylitis ______________________________________________.......2 Psoriatic Arthritis............................... ..................................................................................9 2. IMAGING IN SPONDYLOARTHRITIS .....................................................17 Walter P. Maksymowych Abstract .......................................................................................................................... 17 Introduction........ ..............................................................................,.·...............·..........·.... 17 Plain Radiography.... .......................................................................................................18 Computed Tomography ....................................________.______________.______.__21 Isotonic іпшрііш ............... . .... ..... ..... 21 Ultrasound .........................................................................................................................22 Magnetic Resonance Imaging ........................................................................................... 22 Sacroiliac Joint ................................................................................................................... 24 Spine ..............................................................__.__________............................................27 Conclusions ......................................................................................................................... 33 3. SPONDYLOARTHRITIS, DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS (DISH) AND CHONDROCALCINOSIS _______37 Jácome Brügues Armas, Ana Rita Couto and Bruno Filipe Bettencourt Abstract............................................................................................. __.............................37 Introduction. .......................................................................................................................37 Snondvlnarthrirfa ..................... .........·..............................■..... 37 ^ J * *» f ЛЧЈШЛЖ* (Ul AVrSU ..•.........•...■■.■■■■....V ■·· ■■■■■ 99 ■··■■··» ■··»» ■ W · ■»■ ■■ »· ■»■»»»»»■» »» »■■■■»-—»»- — » w ч· т ·» · » · · ~™ » ■»» ■н Diffuse Idiopathic Skeletal Hyperostosis (DISH)------------------------------------------- 40 Chondrocalcinosis/Crystal Deposition Disease (Cppd CDD) --------.—.----------------40 Molecular Genetics ______________»____________________________________42 Conclusiθns·■■■■■■н······.■■■■.··„.·■■··н■■■..■....n...........-■..■.■··^..».....·„·.■.··.■....■·**. ■.„·.»... 47 xviii Contents 4. THE ENTHESIS ORGAN CONCEPT AND ITS RELEVANCE TO THE SPONDYLOARTHROPATHIES ..........................................57 Michael Benjamin and Dennis McGonagle Abstract ...............................................................................................................................57 Introduction ........................................................................................................................58 Enthesis Organ Structure ..................................................................................................58 Mechanisms for Reducing Stress Concentration at tbe Enthesis Itself ........................63 Related Concepts ................................................................................................................66 Conclusions ..................................____________________..........................------..........67 5. SYNOVIAL AND MUCOSALIMMUNOPATHOLOGY IN SPONDYLOARTHRITIS .................................................................71 Bemard Vandooren, Paul P. Так and Dominique Baeten Abstract....................................»...»........·. ..........................................................................71 Introduction ..............................................................------------------------------------------71 Axial Versus Peripheral Spondyloarthritis ---------------------------------------------------73 Skeletal Remodeling in Spondyoarthritis ----------------------------------------------------73 Synovial Biomarkers in Spondyoarthritis .......................................................................75 Gut Inflammation in Spondyloarthritis —..................................................................... 76 The Pathogenesis of Spondyloarthritis·. The Mucosa Hypothesis .................................77 Innate Immunity and Mucosal Inflammation .................................................................77 Adaptive Immunity and Mucosal Inflammation .............................................................78 The Pathogenesis of Joint Inflammation ..........................................................................78 Conclusions .........................................................................................................................79 6. BONE LOSS IN THE SPONDYLOARTHROPATHIES: ROLE OF OSTEOCLAST, RANKL, RANK AND OPG IN THE SPONDYLOARTHROPATHIES ...........................................85 Allen P. Anandarajah and Edward M. Schwarz Abstract ...............................................................................................................................85 Introduction ........................................................................................................................85 Pathogenesis of Bone Loss .................................................................................................86 Bone Loss in the Spondyloarthritis ..................................................................................91 Bone Loss in Ankylosing Spondylitis ___________._______________.____________91 Bone Loss in PsA .......................................................................................................93 Bone Loss in Enteropathic Arthritis _______________________________________93 Bone Loss in Reactive Arthritis ___________________________________________95 Conclusions ............................................................................................................ 95 Contenu xix 7. RANKL/RANK AS KEY FACTORS FOR OSTEOCLAST DEVELOPMENT AND BONE LOSS IN ARTHROPATHIES ____100 Andreas Leibbrandt and Josef M. Penningar Abstract ___________......................................................................................................100 Introduction..................... .................................................................................................100 Basic Characteristics of the Rankl-Rank-Opg Axis ......................................................101 RANKL-RANK-OPG Interactions and Bone Remodeling.» .......................................104 RANK(L) Signaling Pathways ........................................................................................104 Modulators of Rankl-Mediated Osteoclastogenesis __________________________107 Rank-Rankl as Therapeutic Targets for Arthropathies ...............................................109 Conclusions .......................................................................................................................110 8. BONE FORMATION VERSUS BONE RESORPTION INANKYLOSINGSPONDYLITIS .....................................................114 Georg Schett Abstract .............................................................................................................................114 Introduction* ...............■......■■.·■■.·......,..............·.....·..·..·.............................■.......·...............114 Lessons from Rheumatoid Arthritis ...............................................................................114 Structural Damage in Ankylosing Spondylitis ..............................................................115 Mechanism of Joint Formation — Molecular Lessons for Joint Fusion ......................115 Bony Protrusion as a Stress Response of the Joint ___.................................................115 Osteoblast — The Bone Forming Cells.. ___.___._________________._______........ 116 From the Osteoblast to the Osteophyte ..................................................................------116 Molecular Regulation of Osteophytes ....................................................................»......116 Concepts of Osteophyte Formation ............................................................................—117 Why Do Osteophytes Grow in AS and not in RA? .......................................................118 Conclusions .......................................................................................................................120 9. BIOMARKERS IN SPONDYLOARTHROPATHIES ________________122 Chun-Hsiung Chen, David Так Yan Yu and Chung-Tei Chou Abstract .............................................................................................................................122 Introduction............................................................... .—...............—.■............................... 322 Purpose of Developing Biomarkers in Ankylosing Spondyltis ----------------.--------122 How do Investigators Assess the Degree of Usefulness of Spondylitis Biomarkers? ------------»------.--------------------------------------—.125 Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TTMPs) ______________________________________125 Expression of MMP-3 in Ankylosing Spondylitis ---------------„----------------_.„„-.. 126 Correlation between Serum MMP-3 and Disease Activity...» ---------------------------126 Sensitivity and Specificity of Serum MMP-3 in Evaluation of Disease Activity ______________________________________-------------- 126 Changes of Serum MMP-3 in Response to Therapies ...-------------------.------.------. 127 и Contents Serum ММР-З as Predictor of Disease Progression ___...............................................127 Are Molecules Reflecting Cartilage Turnover Biomarkers of Ankylosing Spondylitis? .............................-...............................................................................128 Macrophage Colony Stimulating Factor (M-CSF) _______________.........................128 Serum Amyloid A (SAA) ..................................................................................................128 Interleukin-6(IL-6) .........................................................................................................129 Conclusions. ..,..................·........·.........·.....·..■·.····...·.■··.....·.............................................. 129 10. THERAPY OF SPONDYLOARTHRITIDES ..........................................133 Jürgen Braun Abstract ........................................________________...................................................133 Introduction. .......... ...........·.............·.........·...........·...·.....■■·.··.··■■..·.-..·..«.«..........>·.·. ..,»..>. 133 Management..... ................................................................................................................134 Imaging ..·..............·...........·.............·.......·...·......,......·.·.·.·...·.....·.■.·.·...·.■.·.·.-.■··...·....·-.....-. 138 Conclusions .......................·.......................·...................,■..···.···■■■···.·.·..■··■...·.■.-.■.■...■.....■. 143 11. GENOMEWIDE SCREENS IN ANKYLOSING SPONDYLITIS ______________________________________________148 Matthew A. Brown Abstract ................................................................................-...........................................148 Introduction·.........·......«..«.·....,......, .......·.,.......................................................................148 Methods for Identifying Disease-Causing Genes .....................»...................................149 Linkage Studies and Ankylosing Spondylitis ................................................................150 High Density Association Studies and Ankylosing Spondylitis ....................................151 MHC Genetics of Ankylosing Spondylitis __________________________________153 Future Studies ..................................................................................................................154 Conclusions .......................................................................................................................155 12. SUBTYPES OF HLA-B27: HISTORY AND IMPLICATIONS IN THE PATHOGENESIS OF ANKYLOSING SPONDYLITIS.... 159 John D. Reveille Abstract ___....._________,_________...........................................................................159 Introduction ......................................................................................................................159 HLA-B27 Subtypes Associations with AS _____................................_________.....__166 The Lack of Disease Association of HLA-B2706 and HLA-B2709 ..........................167 How Amino Acid Differences Between HLA-B27 Subtypes May Impact on Disease Pathogenesis ...........................................................................................167 Conclusions. ___________...............................................................................................172 Contents xxi 13. IMPLICATIONS OF STRUCTURAL AND THERMODYNAMIC STUDIES OFHLA-B27 SUBTYPES EXHIBITING DIFFERENTIAL ASSOCIATION WITH ANKYLOSING SPONDYLITIS .....................................................................................177 Andreas Ziegler, Bernhard Loll, Rolf Missel witz and Barbara Uchanska-Ziegler Abstract .............................................................................................................................177 Introduction ......................................................................................................................178 General Structural Properties of HLA Class I Molecules ............................................178 HLA-B27 Subtypes Exhibiting Differential Disease Association ________________180 HLA-B27: Peptide Complexes for Structural and Other Biophysical Studies ___________.........................................................180 Structural Studies with the m9 Peptide .........................................................................181 Structural Studies with the Proven HLA-B27 Self-Peptide Tis ...................................183 Structural Studies of the Viral Peptide pLMP2 ............................................................185 HLA-B27 Subtype Dependent Conformational Peptide Dimorphisms ............................................................................................................186 HLA-B27 Subtype- and Peptide-Dependent Molecular Mimicry ...............................187 Thermodynamic Analyses of Selected HLA-B27: Peptide Complexes .......................189 Conclusions .......................................................................................................................192 14. HLA-B27-BOUND PEPTIDE REPERTOIRES: THEIR NATURE, ORIGIN AND PATHOGENETIC RELEVANCE .............................196 José A. López de Castro Abstract .............................................................................................................................196 Introduction ......................................................................................................................196 HLA-B27 Polymorphism and Association to AS ...........................................................196 Peptide Specificity of HLA-B27 Subtypes _______________......................................199 T-Cell Presentation of Shared Ligands by HLA-B27 Subtypes _________________202 Molecular Mimicry between Self and Foreign Ligands of HLA-B27 ____._____.—203 The Origin of HLA-B27-Bound Peptide Repertoires: Role of the Proteosome ------204 Assisted Loading of the HLA-B27 Peptide Cargo ___________________________204 Conclusions ..................................................................................................................206 15. BIOCHEMICAL FEATURES OF HLA-B27 AND ANTIGEN PROCESSING .......................................................................................210 Simon J. Powis, Susana G. Santos and Antony N. Antóniou Abstract........................................................................-...-...............·..—. .....—.·......- -....-210 Introduction...................,....™.™..-.....™.™..™.............·.............··.···.— —·«—·· ■■····-——210 The MHC Class I Assembly Pathway ------------------------------------------------------211 A Key Role for Cys-67? _______________________________________________212 HLA-B27 in Dendritic Cells ____________________________________________213 Conclusions ·■■■.·■·»·.··■■··■.··■·.■■··■■■··■··■■·■·■■>··■··■■·■■·■ ■·················■···■·····■··»»·» ·· ··«···■·■·····■·· 214 їхц Contents 16. HLA-B27 MISFOLDING AND SPONDYLOARTHROPATHIES ........217 Robert A. Colbert, Monica L. DeLay, Gerlinde Layh-Schmitt and Dawn P. Sowders Abstract................................«......·.·.« ...............................................................................217 Introduction ......................................................................................................................217 Usual, Unusual and Unique Features of HLA-B27 and Their Potential Role in Disease Pathogenesis .................................................218 Importance of Protein Folding. .......................................................................................219 Consequences of Protein Misfolding ..............................................................................220 HLA-B27 Misfolding .......................................................................................................222 Evaluating the Role of HLA-B27 in Disease ..................................................................223 HLA-B27 Subtypes and Spondyloarthritis ....................................................................228 Overexpression of Additional hß,m: The Model of SpA, ..............................................229 Conclusions ·.··■.■■■■■■■■.■·■·■■■■■··········>«········»■■»··■··········>····■■·■·············■»·>·■·>·■··■······»········ 229 17. HLA-B27 AND HOST-PATHOGEN INTERACTION ...........................235 Anna S. Sahlberg, Kaisa Granfors and Markus A. Penttinen Abstract .............................................................................................................................235 Introduction ......................................................................................................................235 The Molecular Characteristics of HLA-B27 .................................................................236 HLA-B27 and Host-Pathogen Interaction .....................................................................236 HLA-B27 and Host Cell-Pathogen Interaction .............................................................237 HLA-B27 and Survival of Intracellular ReA-Triggering Bacteria .............................238 HLA-B27, ER Stress-Induced Signal Transduction Pathways and Host-Pathogen Interaction ...............................................................................239 HLA-B27 and LPS-Induced Inflammatory Response ..................................................240 Conclusions ..................·.....................·.·......·..................................................................... 241 18. ANIMAL MODELS OF SPONDYLOARTHRITIS ................................245 Joel D. Taurog Abstract .............................................................................................................................245 Introduction................... .............................·.·...............·................................................... 245 Naturally Occurring Spondyloarthritis in Primates __...............................................245 Proteoglycan-Induced Spondylitis and Arthritis in Mice ____.....................................246 Naturally Occurring Spontaneous Models ....................................................................246 Ankylosing Enthesopathy ................................................................................................247 HLA-B27 Transgenic Mice ......................................................................„......................248 TNFTransgenicMice.... ...................................................................................................248 HLA-B27 Transgenic Rats ..............................................................................................248 A New, Improved AS Model in HLA-B27 Transgenic Rats .........................................249 Conclusions............ ..........................................................................................................250 Contents xxiii 19. Т -CELL RESPONSES AGAINST VIRAL AND SELF-EPITOPES AND HLA-B27 SUBTYPES DIFFERENTIALLY ASSOCIATED WITH ANKYLOSING SPONDYLITIS .............................................255 María T. Fiorillo and Rosa Sorrentino Abstract .............................................................................................................................255 Introduction ......................................................................................................................255 Searching for the Holy Grail: From lOT-Restricted Viral Antigens to Self-Ligands Eliciting Autoreactive Cytotoxic Т -Cell Responses in Patients with Ankylosing Spondylitis .................................................................256 Extension of Т -Cell Cross-Reactivity to a Third Player: pGR. ....................................259 T-Cell Cross-Reactivity between Self and Non-Self: The tCR Point of View .............260 Conclusions .......................................................................................................................261 20. DENDRITIC CELL: Т -CELL INTERACTIONS INSPONDYLOARTHRITIS ...............................................................263 J.S. Hill Gaston, Lorna В. Jarvis, Libin Zhang and Jane С Goodall Abstract .............................................................................................................................263 Introduction ......................................................................................................................263 A Novel Subset of CD8+ Τ Cells ......................................................................................264 The Influence of the Unfolded Protein Response on DC Function ..............................270 Conclusions .......................................................................................................................275 21. THE ROLE OF B27 HEAVY CHAIN DIMER IMMUNE RECEPTOR INTERACTIONS IN SPONDYLOARTHRITIS ____277 Simon Kollnberger and Paul Bowness Abstract .............................................................................................................................277 Introduction ......................................................................................................................277 Leukocytes Express Cell Surface B27 Heavy Chain Homodimers. -------..................278 Immune Receptors Interacting with HLA-B27 Heterotrimers and Dimers ---------279 Differential Binding of B272 and B27 Heterotrimers to KIR, LILR and PIR --------281 Involvement of KnmH^-Expressing Т -Cells and NK-Cells in Spondyloarthritis ................................................................................ ..........„..282 Conclusions .......................................................................................................................282 22. KIR GENES AND THEIR ROLE IN SPONDYLOARTHROPATHIES ..................................................286 Roberto Díaz-Peña, Miguel Ángel Blanco-Gelaz and Carlos López-Larrea Abstract ___________________.________________________.__________-286 Introduction........................................................................·...........—··«.— ..·.·——............ 286 Complexity of KIR Family ________________________________■-----------· 287 ÖR and Spondyloarthropathies ____________________________________ 292 Conclusions........... .............__...................................................—.....—.............—...295 xxiv Contents 23. INNATE IMMUNITY OF SPONDYLOARTHRITIS: THE ROLE OF TOLL-LIKE RECEPTORS .........................................................300 Robert D. Inman Abstract ______________________________________________________300 Introduction ......................................................................................................................300 Current Concepts in Innate Immunity ..........................................................................301 Innate Immunity in Host Response to Arthritogenic Bacteria ....................................302 Innate Immunity and Spondyloarthritis ...............................................................____304 Conclusions ..............................................„..............„..............................„.......................307 INDEX .................................................................................................................311
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illustrated	Illustrated
indexdate	2024-12-20T13:40:38Z
institution	BVB
isbn	9781441902979
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-017740264
oclc_num	317664246
open_access_boolean
owner	DE-12 DE-355 DE-BY-UBR
owner_facet	DE-12 DE-355 DE-BY-UBR
physical	XXV, 314 S. Ill., graph. Darst., Kt. 235 mm x 155 mm
publishDate	2009
publishDateSearch	2009
publishDateSort	2009
publisher	Springer Science + Business Media LLC [u.a.]
record_format	marc
series	Advances in experimental medicine and biology
series2	Advances in experimental medicine and biology
spellingShingle	Molecular mechanisms of spondyloarthropathies Advances in experimental medicine and biology Spondylarthropathies genetics Spondyloarthropathies Molecular aspects Spondylarthrose (DE-588)4295946-9 gnd Wirbelsäulenkrankheit (DE-588)4066368-1 gnd
subject_GND	(DE-588)4295946-9 (DE-588)4066368-1
title	Molecular mechanisms of spondyloarthropathies
title_auth	Molecular mechanisms of spondyloarthropathies
title_exact_search	Molecular mechanisms of spondyloarthropathies
title_full	Molecular mechanisms of spondyloarthropathies ed. by Carlos López-Larrea ... [Participants: Allen P. Amandarajah ...]
title_fullStr	Molecular mechanisms of spondyloarthropathies ed. by Carlos López-Larrea ... [Participants: Allen P. Amandarajah ...]
title_full_unstemmed	Molecular mechanisms of spondyloarthropathies ed. by Carlos López-Larrea ... [Participants: Allen P. Amandarajah ...]
title_short	Molecular mechanisms of spondyloarthropathies
title_sort	molecular mechanisms of spondyloarthropathies
topic	Spondylarthropathies genetics Spondyloarthropathies Molecular aspects Spondylarthrose (DE-588)4295946-9 gnd Wirbelsäulenkrankheit (DE-588)4066368-1 gnd
topic_facet	Spondylarthropathies genetics Spondyloarthropathies Molecular aspects Spondylarthrose Wirbelsäulenkrankheit
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017740264&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
volume_link	(DE-604)BV000003102
work_keys_str_mv	AT lopezlarreacarlos molecularmechanismsofspondyloarthropathies AT anandarajahallenp molecularmechanismsofspondyloarthropathies

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