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| Title: | Messenger RNA Therapeutics |
|---|---|
| From: |
edited by Stefan Jurga, Jan Barciszewski.
|
| Person: |
Jurga, Stefan.
Barciszewski, Jan. editor. |
| Corporate Author: | |
| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham :
Springer International Publishing : Imprint: Springer,
2022.
|
| Edition: | 1st ed. 2022. |
| Series: | RNA Technologies,
13 |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-031-08415-7 |
| Summary: | This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics. |
| Physical Description: | 1 Online-Ressource (XII, 446 p. 68 illus., 57 illus. in color.) |
| ISBN: | 9783031084157 |
| ISSN: | 2197-9758 ; |
Staff View
MARC
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| 505 | 0 | |a The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications - Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications. | |
| 520 | |a This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics. | ||
| 650 | 0 | |a Medical genetics. | |
| 650 | 0 | |a Medicinal chemistry. | |
| 650 | 0 | |a Nanomedicine. | |
| 650 | 0 | |a Cancer |x Treatment. | |
| 650 | 1 | 4 | |a Medical Genetics. |
| 650 | 2 | 4 | |a Medicinal Chemistry. |
| 650 | 2 | 4 | |a Nanomedicine and Nanotoxicology. |
| 650 | 2 | 4 | |a Cancer Therapy. |
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| 700 | 1 | |a Barciszewski, Jan. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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Record in the Search Index
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| _version_ | 1835726561321418752 |
| adam_text | |
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| author2 | Jurga, Stefan Barciszewski, Jan |
| author2_role | edt edt |
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| author_facet | Jurga, Stefan Barciszewski, Jan SpringerLink (Online service) |
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| callnumber-first | R - Medicine |
| callnumber-label | RB155-155 |
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| contents | The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications - Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications. |
| dewey-full | 616.042 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.042 |
| dewey-search | 616.042 |
| dewey-sort | 3616.042 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1st ed. 2022. |
| format | Electronic eBook |
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| id | ZDB-2-SBL-978-3-031-08415-7 |
| illustrated | Not Illustrated |
| indexdate | 2025-06-23T13:27:53Z |
| institution | BVB |
| isbn | 9783031084157 |
| issn | 2197-9758 ; |
| language | English |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (XII, 446 p. 68 illus., 57 illus. in color.) |
| psigel | ZDB-2-SBL UBG_PDA_SBL ZDB-2-SBL ZDB-2-SXB |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | Springer International Publishing : Imprint: Springer, |
| record_format | marc |
| series | RNA Technologies, |
| series2 | RNA Technologies, |
| spelling | Messenger RNA Therapeutics [electronic resource] / edited by Stefan Jurga, Jan Barciszewski. 1st ed. 2022. Cham : Springer International Publishing : Imprint: Springer, 2022. 1 Online-Ressource (XII, 446 p. 68 illus., 57 illus. in color.) text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda RNA Technologies, 2197-9758 ; 13 The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications - Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications. This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics. Medical genetics. Medicinal chemistry. Nanomedicine. Cancer Treatment. Medical Genetics. Medicinal Chemistry. Nanomedicine and Nanotoxicology. Cancer Therapy. Jurga, Stefan. editor. edt http://id.loc.gov/vocabulary/relators/edt Barciszewski, Jan. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9783031084140 Printed edition: 9783031084164 Printed edition: 9783031084171 |
| spellingShingle | Messenger RNA Therapeutics RNA Technologies, The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications - Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications. Medical genetics. Medicinal chemistry. Nanomedicine. Cancer Treatment. Medical Genetics. Medicinal Chemistry. Nanomedicine and Nanotoxicology. Cancer Therapy. |
| title | Messenger RNA Therapeutics |
| title_auth | Messenger RNA Therapeutics |
| title_exact_search | Messenger RNA Therapeutics |
| title_full | Messenger RNA Therapeutics [electronic resource] / edited by Stefan Jurga, Jan Barciszewski. |
| title_fullStr | Messenger RNA Therapeutics [electronic resource] / edited by Stefan Jurga, Jan Barciszewski. |
| title_full_unstemmed | Messenger RNA Therapeutics [electronic resource] / edited by Stefan Jurga, Jan Barciszewski. |
| title_short | Messenger RNA Therapeutics |
| title_sort | messenger rna therapeutics |
| topic | Medical genetics. Medicinal chemistry. Nanomedicine. Cancer Treatment. Medical Genetics. Medicinal Chemistry. Nanomedicine and Nanotoxicology. Cancer Therapy. |
| topic_facet | Medical genetics. Medicinal chemistry. Nanomedicine. Cancer Treatment. Medical Genetics. Medicinal Chemistry. Nanomedicine and Nanotoxicology. Cancer Therapy. |
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