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| Title: | The Calabar Bean and its Alkaloids From Magic, via Miracle, to Memory / |
|---|---|
| Person: |
Robinson, Brian.
author. aut http://id.loc.gov/vocabulary/relators/aut |
| Main Author: | |
| Corporate Author: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2023.
|
| Edition: | 1st ed. 2023. |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-94-024-1191-1 |
| Summary: | Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a "lead compound") have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial. |
| Physical Description: | 1 Online-Ressource (XXVI, 267 p. 240 illus.) |
| ISBN: | 9789402411911 |
Staff View
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| 505 | 0 | |a Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index. | |
| 520 | |a Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a "lead compound") have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial. | ||
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| contents | Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index. |
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| edition | 1st ed. 2023. |
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| isbn | 9789402411911 |
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| spelling | Robinson, Brian. author. aut http://id.loc.gov/vocabulary/relators/aut The Calabar Bean and its Alkaloids [electronic resource] : From Magic, via Miracle, to Memory / by Brian Robinson. 1st ed. 2023. Dordrecht : Springer Netherlands : Imprint: Springer, 2023. 1 Online-Ressource (XXVI, 267 p. 240 illus.) text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index. Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a "lead compound") have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial. Botanical chemistry. Chemistry, Organic. Pharmaceutical chemistry. Plant Biochemistry. Organic Chemistry. Pharmaceutics. SpringerLink (Online service) Springer Nature eBook Printed edition: 9789402411904 Printed edition: 9789402411928 |
| spellingShingle | Robinson, Brian The Calabar Bean and its Alkaloids From Magic, via Miracle, to Memory / Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index. Botanical chemistry. Chemistry, Organic. Pharmaceutical chemistry. Plant Biochemistry. Organic Chemistry. Pharmaceutics. |
| title | The Calabar Bean and its Alkaloids From Magic, via Miracle, to Memory / |
| title_auth | The Calabar Bean and its Alkaloids From Magic, via Miracle, to Memory / |
| title_exact_search | The Calabar Bean and its Alkaloids From Magic, via Miracle, to Memory / |
| title_full | The Calabar Bean and its Alkaloids [electronic resource] : From Magic, via Miracle, to Memory / by Brian Robinson. |
| title_fullStr | The Calabar Bean and its Alkaloids [electronic resource] : From Magic, via Miracle, to Memory / by Brian Robinson. |
| title_full_unstemmed | The Calabar Bean and its Alkaloids [electronic resource] : From Magic, via Miracle, to Memory / by Brian Robinson. |
| title_short | The Calabar Bean and its Alkaloids |
| title_sort | calabar bean and its alkaloids from magic via miracle to memory |
| title_sub | From Magic, via Miracle, to Memory / |
| topic | Botanical chemistry. Chemistry, Organic. Pharmaceutical chemistry. Plant Biochemistry. Organic Chemistry. Pharmaceutics. |
| topic_facet | Botanical chemistry. Chemistry, Organic. Pharmaceutical chemistry. Plant Biochemistry. Organic Chemistry. Pharmaceutics. |
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