Gespeichert in:
| Titel: | Hypoxia in Cancer: Significance and Impact on Cancer Therapy |
|---|---|
| Von: |
edited by Sukhes Mukherjee, Jagat Rakesh Kanwar.
|
| Person: |
Mukherjee, Sukhes.
Kanwar, Jagat Rakesh. editor. |
| Körperschaft: | |
| Weitere beteiligte Personen: | , |
| Format: | Elektronisch E-Book |
| Sprache: | Englisch |
| Veröffentlicht: |
Singapore :
Springer Nature Singapore : Imprint: Springer,
2023.
|
| Ausgabe: | 1st ed. 2023. |
| Schlagwörter: | |
| Medienzugang: | https://doi.org/10.1007/978-981-99-0313-9 |
| Zusammenfassung: | This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches. |
| Umfang: | 1 Online-Ressource (XV, 447 p. 1 illus.) |
| ISBN: | 9789819903139 |
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| 505 | 0 | |a Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy - Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance. | |
| 520 | |a This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches. | ||
| 650 | 0 | |a Cancer. | |
| 650 | 0 | |a Cancer |x Treatment. | |
| 650 | 0 | |a Tumors |x Immunological aspects. | |
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| 650 | 2 | 4 | |a Cancer Biology. |
| 650 | 2 | 4 | |a Tumour Immunology. |
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| 700 | 1 | |a Kanwar, Jagat Rakesh. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| contents | Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy - Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance. |
| dewey-full | 571.978 616.994 |
| dewey-hundreds | 500 - Natural sciences and mathematics 600 - Technology (Applied sciences) |
| dewey-ones | 571 - Physiology & related subjects 616 - Diseases |
| dewey-raw | 571.978 616.994 |
| dewey-search | 571.978 616.994 |
| dewey-sort | 3571.978 |
| dewey-tens | 570 - Biology 610 - Medicine and health |
| discipline | Biologie Medizin |
| edition | 1st ed. 2023. |
| format | Electronic eBook |
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| id | ZDB-2-SBL-978-981-99-0313-9 |
| illustrated | Not Illustrated |
| indexdate | 2025-06-23T13:27:55Z |
| institution | BVB |
| isbn | 9789819903139 |
| language | English |
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| physical | 1 Online-Ressource (XV, 447 p. 1 illus.) |
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| spelling | Hypoxia in Cancer: Significance and Impact on Cancer Therapy [electronic resource] / edited by Sukhes Mukherjee, Jagat Rakesh Kanwar. 1st ed. 2023. Singapore : Springer Nature Singapore : Imprint: Springer, 2023. 1 Online-Ressource (XV, 447 p. 1 illus.) text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy - Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance. This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches. Cancer. Cancer Treatment. Tumors Immunological aspects. Cancers. Cancer Therapy. Cancer Biology. Tumour Immunology. Mukherjee, Sukhes. editor. edt http://id.loc.gov/vocabulary/relators/edt Kanwar, Jagat Rakesh. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer Nature eBook Printed edition: 9789819903122 Printed edition: 9789819903146 Printed edition: 9789819903153 |
| spellingShingle | Hypoxia in Cancer: Significance and Impact on Cancer Therapy Chapter 1. Hypoxia and its Biological Implications for Cancer Therapy -- Chapter 2. Hypoxia's function in cancer -- Chapter 3. Role of Hypoxia and Reactive Oxygen Species in cancer biology -- Chapter 4. Hypoxic tumor microenvironment: driver for cancer progression -- Chapter 5. Hypoxia and Senescence: Role of Oxygen in Modulation of Tumor Suppression -- Chapter 6. Hypoxia Regulated Gene Expression and Metastasis -- Chapter 7. piRNA based cancer therapy in hypoxic tumor -- Chapter 8. MicroRNA Signatures of Tumor Hypoxia -- Chapter 9. Hypoxia and the Metastatic Cascade -- Chapter 10. Hypoxia and Extra Cellular Matrix-major drivers of tumor Metastasis -- Chapter 11. Role of Hypoxia in Cancer Therapy - Introduction -- Chapter 12. Hypoxic regulation of telomerase gene expression in cancer -- Chapter 13. CRISPR/Cas9-editing-based modeling of tumor hypoxia -- Chapter 14. Tumor-on-a-chip: Microfluidic models for Hypoxic tumor microenvironment -- Chapter 15. Imaging the Hypoxic Tumor microenvironment in cancer models -- Chapter 16. Hypoxia-targeting drugs as new cancer chemotherapy agents Hypoxia-targeting drugs as new cancer chemotherapy agents - Molecular Insights -- Chapter 17. Identification of Hypoxia targeting drugs in the tumor microenvironment and prodrug Strategies for Targeting Tumor Hypoxia -- Chapter 18. Hypoxia Induced Apoptosis in Cancer Development -- Chapter 19. Hypoxia in drug resistance and radioresistance. Cancer. Cancer Treatment. Tumors Immunological aspects. Cancers. Cancer Therapy. Cancer Biology. Tumour Immunology. |
| title | Hypoxia in Cancer: Significance and Impact on Cancer Therapy |
| title_auth | Hypoxia in Cancer: Significance and Impact on Cancer Therapy |
| title_exact_search | Hypoxia in Cancer: Significance and Impact on Cancer Therapy |
| title_full | Hypoxia in Cancer: Significance and Impact on Cancer Therapy [electronic resource] / edited by Sukhes Mukherjee, Jagat Rakesh Kanwar. |
| title_fullStr | Hypoxia in Cancer: Significance and Impact on Cancer Therapy [electronic resource] / edited by Sukhes Mukherjee, Jagat Rakesh Kanwar. |
| title_full_unstemmed | Hypoxia in Cancer: Significance and Impact on Cancer Therapy [electronic resource] / edited by Sukhes Mukherjee, Jagat Rakesh Kanwar. |
| title_short | Hypoxia in Cancer: Significance and Impact on Cancer Therapy |
| title_sort | hypoxia in cancer significance and impact on cancer therapy |
| topic | Cancer. Cancer Treatment. Tumors Immunological aspects. Cancers. Cancer Therapy. Cancer Biology. Tumour Immunology. |
| topic_facet | Cancer. Cancer Treatment. Tumors Immunological aspects. Cancers. Cancer Therapy. Cancer Biology. Tumour Immunology. |
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